092 “ALARMINS” S100A8 AND A9 ARE ACTIVELY INVOLVED IN REGULATION OF CARTILAGE DESTRUCTION DURING OSTEOARTHRITIS

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

BACKGROUND Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C...

S100A8/A9 increases the mobilization of pro-inflammatory Ly6C monocytes to the synovium during experimental osteoarthritis

Background: Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6C and patrolling Ly6C monocytes. Alarmins S100A8/A9 locally released by the synovium during inflammatory OA for prolonged periods may be dominant proteins involved in stimulating recruitment of Ly6C monoc...

Mechanism of cartilage destruction in osteoarthritis.

Osteoarthritis (OA) is one of the most common diseases among the elderly. For many years, OA was considered a normal result of the aging process with few treatment options. Remarkable progress in understanding OA cartilage has been achieved in recent years. The application of technical advances to clinical studies of chondrocytes and cartilage tissue metabolism will provide important new insigh...

Molecular mechanisms of cartilage destruction in osteoarthritis.

IL-22/IL-22R1 axis and S100A8/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts.

OBJECTIVES Fibroblast-like synoviocytes (FLSs) are crucial players in the pathogenesis of synovitis in rheumatic diseases. Targeting FLS activation represents an approach to the development of therapeutic strategies. Our aim was to investigate whether the microenvironment of inflamed joints could modulate the expression of IL-22 and IL-22R1 on OA and RA FLSs. We also examined the effect of IL-2...